UniProt ID: Q1LXD2 |
FUNCTION: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling. {ECO:0000256|RuleBase:RU361268}. SUBUNIT: Tetramer of two alpha and two beta subunits. {ECO:0000256|RuleBase:RU361268}. SIMILARITY: Belongs to the casein kinase 2 subunit beta family. {ECO:0000256|ARBA:ARBA00006941, ECO:0000256|RuleBase:RU361268}. |
UniProt ID: Q91398 |
FUNCTION: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity). Participates in Wnt signaling (By similarity). {ECO:0000250|UniProtKB:P67870, ECO:0000250|UniProtKB:P67871}. SUBUNIT: Casein kinase II/CK2 is a tetramer composed of two alpha subunits and two beta subunits. The beta subunit dimerization is mediated by zinc ions. {ECO:0000250, ECO:0000250|UniProtKB:P67870}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P67870}. DOMAIN: The KSSR motif is part of a protein interaction pocket that mediates interaction with cellular and viral proteins. {ECO:0000250|UniProtKB:P67870}. PTM: Phosphorylated by alpha subunit. {ECO:0000250}. SIMILARITY: Belongs to the casein kinase 2 subunit beta family. {ECO:0000305}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |