UniProt ID: Q98867 |
FUNCTION: High affinity receptor for triiodothyronine (By similarity). In the absence of thyroid hormone during late blastula stage development, acts as a transcriptional repressor. Whereas in the presence of thyroid hormone, can act as an activator of transcription. In addition, represses retinoic acid (RA)-signaling during blastula and gastrula stages of development. {ECO:0000250, ECO:0000269|PubMed:17583703, ECO:0000269|PubMed:9447705}. SUBUNIT: Interacts with ncoa2. {ECO:0000269|PubMed:17583703}. SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:9447705}. TISSUE SPECIFICITY: After the mid-blastula transition (MBT), expressed throughout the deep cells, which give rise to the embryo proper. In adults, isoform 2 shows highest expression in the eye and liver. Expressed in adult gonads. {ECO:0000269|PubMed:9447705}. DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. Most abundant during early oogenesis during stages I and II, and expression levels drop by oocyte maturation. Expressed at the 1-cell stage and then again after the MBT from the blastula to early gastrula (shield) stages, during which expression levels decrease. Not detected after gastrulation until adults. {ECO:0000269|PubMed:17583703, ECO:0000269|PubMed:9447705}. DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. {ECO:0000269|PubMed:17583703}. DOMAIN: The C-terminal extension present in isoform 1 and absent in isoform 2 (the F-domain) regulates transcriptional activity by altering the selectivity of binding to cofactors. {ECO:0000269|PubMed:17583703}. SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}. |
UniProt ID: A0A8M3B8B2 |
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00407, ECO:0000256|RuleBase:RU004334}. SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000256|ARBA:ARBA00008092}. |
UniProt ID: B2GQG7 |
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00407, ECO:0000256|RuleBase:RU004334}. SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000256|ARBA:ARBA00008092}. |
UniProt ID: A0A8M2BB68 |
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00407, ECO:0000256|RuleBase:RU004334}. SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000256|ARBA:ARBA00008092}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |