UniProt ID: Q6DGD1 |
SIMILARITY: Belongs to the small GTPase superfamily. Ras family. {ECO:0000256|ARBA:ARBA00008344}. |
UniProt ID: P79737 |
FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. {ECO:0000250|UniProtKB:P01111}. CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000250|UniProtKB:P01116}; ACTIVITY REGULATION: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide- exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P01111}; Lipid-anchor {ECO:0000250|UniProtKB:P01111}; Cytoplasmic side {ECO:0000250|UniProtKB:P01111}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P01111}; Lipid-anchor {ECO:0000250|UniProtKB:P01111}. Note=Shuttles between the plasma membrane and the Golgi apparatus. {ECO:0000250|UniProtKB:P01111}. PTM: Palmitoylated by the ZDHHC9-GOLGA7 complex. Depalmitoylated by abhd17a, abhd17b and abhd17c. A continuous cycle of de- and re- palmitoylation regulates rapid exchange between plasma membrane and Golgi. {ECO:0000250|UniProtKB:P01111}. SIMILARITY: Belongs to the small GTPase superfamily. Ras family. {ECO:0000305}. |
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