UniProt ID: O42354 |
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:Q00987}. CATALYTIC ACTIVITY: Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000250|UniProtKB:Q00987}; SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P23804}. Cytoplasm {ECO:0000250|UniProtKB:P23804}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P23804}. Nucleus {ECO:0000250|UniProtKB:Q00987}. SIMILARITY: Belongs to the MDM2/MDM4 family. {ECO:0000305}. |
UniProt ID: A0A8M2BC69 |
CATALYTIC ACTIVITY: Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900, ECO:0000256|PIRNR:PIRNR006748}; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR006748}. Nucleus, nucleoplasm {ECO:0000256|PIRNR:PIRNR006748}. Nucleus, nucleolus {ECO:0000256|PIRNR:PIRNR006748}. SIMILARITY: Belongs to the MDM2/MDM4 family. {ECO:0000256|ARBA:ARBA00005803, ECO:0000256|PIRNR:PIRNR006748}. |
UniProt ID: Q561Z0 |
CATALYTIC ACTIVITY: Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900, ECO:0000256|PIRNR:PIRNR006748}; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR006748}. Nucleus, nucleoplasm {ECO:0000256|PIRNR:PIRNR006748}. Nucleus, nucleolus {ECO:0000256|PIRNR:PIRNR006748}. SIMILARITY: Belongs to the MDM2/MDM4 family. {ECO:0000256|ARBA:ARBA00005803, ECO:0000256|PIRNR:PIRNR006748}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |