UniProt ID: Q9PTJ3
FUNCTION: Transcription factor that acts synergistically with tal1/scl in primitive and definitive hematopoiesis, and in endothelial development. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hematopoietic induction cues such as gata1, tal1/scl-lmo2-induced haemangioblasts differentiate into endothelial cells. {ECO:0000269|PubMed:14602685, ECO:0000269|PubMed:17090656}.
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P25801}.
TISSUE SPECIFICITY: During embryogenesis, expressed in hematopoietic and endothelial precursors, including the two stripes of posterior and anterior lateral plate mesoderm at the 1- somite stage that give rise to the primitive blood. {ECO:0000269|PubMed:15893977, ECO:0000269|PubMed:9630750}.
INDUCTION: By ets transcription factors including ets1. {ECO:0000269|PubMed:15893977}.
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