UniProt ID: Q92048 |
FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). {ECO:0000250|UniProtKB:P09544, ECO:0000250|UniProtKB:P21552}. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P09544}. Secreted {ECO:0000250|UniProtKB:P09544}. DEVELOPMENTAL STAGE: First detected in the developing viscera at 30 hours. Expression is gone by 5 days. {ECO:0000269|Ref.1}. PTM: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. {ECO:0000250|UniProtKB:P09544}. SIMILARITY: Belongs to the Wnt family. {ECO:0000305}. |
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