FUNCTION: Seems to play a role in dorsal axis formation. {ECO:0000269|PubMed:7768180}. SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. DEVELOPMENTAL STAGE: Detected 4 hours after fertilization with maximum levels seen in 6 hours embryos. Expression then declines during gastrulation (6-10 hours), but is still detectable in 24 and 30 hours embryos. The spatial distribution also varies during embryogenesis: at the beginning, expression is localized in deep cells and is absent from the enveloping layer. The pattern then becomes asymmetric, restricting to the forming embryonic shield. By the shield stage, it is highly localized in the axial hypoblast. As gastrulation proceeds, expression continues in the involuting cells, extending from the margin towards the anterior. {ECO:0000269|PubMed:7768180}. |