UniProt ID: P51028 |
FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Required for mesoderm and neural ectoderm patterning during gastrulation (PubMed:11703928). Involved in axis formation during embryonic development, via activation of canonical Wnt/CTNNB1 signaling (PubMed:11703928, PubMed:25371059). May be involved in the specification of the spatial patterns of expression of Gsc and other regulatory genes leading to the establishment of the embryonic axis (PubMed:7600994). {ECO:0000269|PubMed:11703928, ECO:0000269|PubMed:25371059, ECO:0000269|PubMed:7600994, ECO:0000305}. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q9H1J5}. Secreted {ECO:0000250|UniProtKB:Q9H1J5}. TISSUE SPECIFICITY: Expressed in the margin of the pregastrula embryo destined to be the future mesoderm. {ECO:0000269|PubMed:7600994}. DEVELOPMENTAL STAGE: Expressed in the segmental plate and ventral mesoderm during early gastrulation and early somitogenesis (PubMed:25371059). Expressed in the marginal region and in a broad domain in the ventral region after 75% epiboly (PubMed:11703928). Expressed in the tailbud during the bud stage (PubMed:11703928). {ECO:0000269|PubMed:11703928, ECO:0000269|PubMed:25371059}. PTM: Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity). {ECO:0000250|UniProtKB:P28026, ECO:0000250|UniProtKB:P56704}. PTM: Proteolytic processing by tiki1 and tiki2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of wnt8. {ECO:0000250|UniProtKB:P28026}. SIMILARITY: Belongs to the Wnt family. {ECO:0000305}. |
UniProt ID: Q90YL8 |
FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. {ECO:0000256|RuleBase:RU003500}. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}. SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683, ECO:0000256|RuleBase:RU003500}. |
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