UniProt ID: Q98862
FUNCTION: Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation.
SUBCELLULAR LOCATION: Indian hedgehog B protein N-product: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Extracellular side {ECO:0000250}. Note=The N-terminal peptide remains associated with the cell surface. {ECO:0000250}.
SUBCELLULAR LOCATION: Indian hedgehog B protein C-product: Secreted, extracellular space {ECO:0000250}. Note=The C-terminal peptide diffuses from the cell. {ECO:0000250}.
TISSUE SPECIFICITY: Expressed exclusively in the notochord.
DEVELOPMENTAL STAGE: First detectable at the mid-gastrula stage. Disappears at the end of the somitogenesis.
DOMAIN: The indian hedgehog protein N-product binds calcium and zinc ions; this stabilizes the protein fold and is essential for protein-protein interactions mediated by this domain. {ECO:0000250}.
PTM: The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N- terminal fragment (N-product). The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity (By similarity). {ECO:0000250}.
PTM: Cholesterylation is required for N-product targeting to lipid rafts and multimerization. {ECO:0000250}.
PTM: N-palmitoylation is required for N-product multimerization and full activity. {ECO:0000250}.
SIMILARITY: Belongs to the hedgehog family. {ECO:0000305}.
UniProt ID: F1R9L0
FUNCTION: Intercellular signal essential for a variety of patterning events during development. {ECO:0000256|RuleBase:RU280812}.
SIMILARITY: Belongs to the hedgehog family. {ECO:0000256|RuleBase:RU280812}.
This information was provided by UniProt through a collaboration with ZFIN. (1)