UniProt ID: E7FB58 |
FUNCTION: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C- 27 hydroxylation in the liver. {ECO:0000256|ARBA:ARBA00003133}. CATALYTIC ACTIVITY: Reaction=H(+) + NADP(+) + 2 reduced [adrenodoxin] = NADPH + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:42312, Rhea:RHEA-COMP:9998, Rhea:RHEA- COMP:9999, ChEBI:CHEBI:15378, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.18.1.6; Evidence={ECO:0000256|ARBA:ARBA00000384, ECO:0000256|PIRNR:PIRNR000362}; COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|ARBA:ARBA00001974, ECO:0000256|PIRNR:PIRNR000362, ECO:0000256|PIRSR:PIRSR000362-1}; PATHWAY: Steroid metabolism; cholesterol metabolism. {ECO:0000256|ARBA:ARBA00004731}. SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|PIRNR:PIRNR000362}. SIMILARITY: Belongs to the ferredoxin--NADP reductase type 1 family. {ECO:0000256|ARBA:ARBA00008312, ECO:0000256|PIRNR:PIRNR000362}. |
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