UniProt ID: E7F240 |
FUNCTION: Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether (By similarity). TRAPP II complex has also GEF activity toward RAB1A (By similarity). TRAPPC14 is required for ciliogenesis (PubMed:30715179). {ECO:0000250|UniProtKB:Q3TLI0, ECO:0000250|UniProtKB:Q8WVR3, ECO:0000269|PubMed:30715179}. SUBUNIT: Component of the multisubunit TRAPP II complex, which includes at least TRAPPC1, TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC4, TRAPPC5, TRAPPC6A/B, TRAPPC9, TRAPPC10 and TRAPPC14. TRAPPC9, TRAPPC10 and TRAPPC14 are specific subunits of the TRAPP II complex. Interacts with alpha-tubulin during mitosis. {ECO:0000250|UniProtKB:Q8WVR3}. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8WVR3}. Vesicle {ECO:0000250|UniProtKB:Q8WVR3}. Midbody {ECO:0000250|UniProtKB:Q8WVR3}. Note=During mitosis, precedes alpha-tubulin in gap formation of cell abscission at the midbody and is co-localized with PLK1 at the edges of microtubules extensions of daughter cells post cytokinesis abscission. {ECO:0000250|UniProtKB:Q8WVR3}. DISRUPTION PHENOTYPE: Morpholino knockdown of the protein in early embryos results in curved bodies and small eyes. Morphants exhibit reduced ciliation in otic vesicles, neuromasts, and olfactory placodes (PubMed:31467083). In a knockout model mutant animals show head to body ratios lower than those of controls. They have decreased brain cell proliferation rate at 24 hpf (PubMed:30715179). {ECO:0000269|PubMed:30715179, ECO:0000269|PubMed:31467083}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |