UniProt ID: F8W5P0 |
FUNCTION: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates. {ECO:0000256|RuleBase:RU368068}. CATALYTIC ACTIVITY: Reaction=an S-substituted glutathione + H2O = an S-substituted L- cysteinylglycine + L-glutamate; Xref=Rhea:RHEA:59468, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:90779, ChEBI:CHEBI:143103; EC=3.4.19.13; Evidence={ECO:0000256|RuleBase:RU368068}; CATALYTIC ACTIVITY: Reaction=an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]; Xref=Rhea:RHEA:23904, Rhea:RHEA-COMP:9780, Rhea:RHEA-COMP:9795, ChEBI:CHEBI:77644, ChEBI:CHEBI:78597, ChEBI:CHEBI:78599, ChEBI:CHEBI:78608; EC=2.3.2.2; Evidence={ECO:0000256|RuleBase:RU368068}; CATALYTIC ACTIVITY: Reaction=glutathione + H2O = L-cysteinylglycine + L-glutamate; Xref=Rhea:RHEA:28807, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:57925, ChEBI:CHEBI:61694; EC=3.4.19.13; Evidence={ECO:0000256|RuleBase:RU368068}; PATHWAY: Sulfur metabolism; glutathione metabolism. {ECO:0000256|RuleBase:RU368068}. SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU368068}; Single- pass type II membrane protein {ECO:0000256|RuleBase:RU368068}. SIMILARITY: Belongs to the gamma-glutamyltransferase family. {ECO:0000256|ARBA:ARBA00009381}. |
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