UniProt ID: F8W4H9 |
FUNCTION: Inhibitor of melanocortin receptor 4 (mc4r), a receptor involved in energy homeostasis. Plays a role during larval development in the control of energy homeostasis and body weight regulation by decreasing ligand-sensitivity of mc4r and mc4r-mediated generation of cAMP, leading to stimulate growth during larval development. Acts by stabilizing an inactive conformation of mc4r during embryonic development, when all the energy consumed is obtained from the yolk sac, possibly to speed the rapid maturation to the mobile free-feeding juvenile stage reached at 5 dpf. {ECO:0000269|PubMed:23869017}. SUBUNIT: Interacts with mc4r. {ECO:0000269|PubMed:23869017}. SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. DEVELOPMENTAL STAGE: Expressed from 1 post-fertilization (dpf) and expression increases until 4 dpf. Ubiquitously expressed at 5 dpf. {ECO:0000269|PubMed:23869017}. MISCELLANEOUS: Two paralogs of MRAP2 are present in zebrafish: mrap2a, which plays a role during larval development and mrap2b, which constitutes the ortholog of mammalian MRAP2. {ECO:0000305|PubMed:23869017}. SIMILARITY: Belongs to the MRAP family. {ECO:0000305}. |
UniProt ID: A0A2R8Q573 |
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}. Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. SIMILARITY: Belongs to the MRAP family. {ECO:0000256|ARBA:ARBA00010063}. |
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