UniProt ID: A0A8M1P6A3 |
FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. {ECO:0000256|RuleBase:RU364079}. CATALYTIC ACTIVITY: Reaction=H2O + N-(9Z-octadecenoyl)-sphing-4-enine = (9Z)-octadecenoate + sphing-4-enine; Xref=Rhea:RHEA:41299, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57756, ChEBI:CHEBI:77996; Evidence={ECO:0000256|ARBA:ARBA00000115}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41300; Evidence={ECO:0000256|ARBA:ARBA00000115}; CATALYTIC ACTIVITY: Reaction=an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine; Xref=Rhea:RHEA:20856, ChEBI:CHEBI:15377, ChEBI:CHEBI:28868, ChEBI:CHEBI:52639, ChEBI:CHEBI:57756; EC=3.5.1.23; Evidence={ECO:0000256|ARBA:ARBA00000595}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20857; Evidence={ECO:0000256|ARBA:ARBA00000595}; CATALYTIC ACTIVITY: Reaction=an N-acylsphinganine + H2O = a fatty acid + sphinganine; Xref=Rhea:RHEA:33551, ChEBI:CHEBI:15377, ChEBI:CHEBI:28868, ChEBI:CHEBI:31488, ChEBI:CHEBI:57817; Evidence={ECO:0000256|ARBA:ARBA00000351}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33552; Evidence={ECO:0000256|ARBA:ARBA00000351}; PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004760}. PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}. SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. SIMILARITY: Belongs to the alkaline ceramidase family. {ECO:0000256|ARBA:ARBA00009780, ECO:0000256|RuleBase:RU364079}. |
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