UniProt ID: R4GEU0 |
FUNCTION: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. {ECO:0000256|ARBA:ARBA00002797}. CATALYTIC ACTIVITY: Reaction=acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA; Xref=Rhea:RHEA:21160, ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:456216; EC=2.3.3.8; Evidence={ECO:0000256|ARBA:ARBA00000727}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21162; Evidence={ECO:0000256|ARBA:ARBA00000727}; PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. {ECO:0000256|ARBA:ARBA00005064}. SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881, ECO:0000256|PIRNR:PIRNR036511}. SIMILARITY: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. {ECO:0000256|ARBA:ARBA00005899, ECO:0000256|PIRNR:PIRNR036511}. SIMILARITY: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. {ECO:0000256|ARBA:ARBA00010719, ECO:0000256|PIRNR:PIRNR036511}. |
UniProt ID: A0A8M9QMV2 |
FUNCTION: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. {ECO:0000256|ARBA:ARBA00002797}. CATALYTIC ACTIVITY: Reaction=acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA; Xref=Rhea:RHEA:21160, ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:456216; EC=2.3.3.8; Evidence={ECO:0000256|ARBA:ARBA00000727}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21162; Evidence={ECO:0000256|ARBA:ARBA00000727}; PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. {ECO:0000256|ARBA:ARBA00005064}. SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881, ECO:0000256|PIRNR:PIRNR036511}. SIMILARITY: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. {ECO:0000256|ARBA:ARBA00005899, ECO:0000256|PIRNR:PIRNR036511}. SIMILARITY: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. {ECO:0000256|ARBA:ARBA00010719, ECO:0000256|PIRNR:PIRNR036511}. |
UniProt ID: F1R515 |
FUNCTION: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. {ECO:0000256|ARBA:ARBA00002797}. CATALYTIC ACTIVITY: Reaction=acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA; Xref=Rhea:RHEA:21160, ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:456216; EC=2.3.3.8; Evidence={ECO:0000256|ARBA:ARBA00000727}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21162; Evidence={ECO:0000256|ARBA:ARBA00000727}; PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. {ECO:0000256|ARBA:ARBA00005064}. SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881, ECO:0000256|PIRNR:PIRNR036511}. SIMILARITY: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. {ECO:0000256|ARBA:ARBA00005899, ECO:0000256|PIRNR:PIRNR036511}. SIMILARITY: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. {ECO:0000256|ARBA:ARBA00010719, ECO:0000256|PIRNR:PIRNR036511}. |
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