UniProt ID: Q6P3G4 |
FUNCTION: Plays a role in embryonic development, including proper left- right asymmetry formation. Also required for proper cilia beating (PubMed:22493317). Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (By similarity). {ECO:0000250|UniProtKB:Q6IQ19, ECO:0000269|PubMed:22493317}. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q6IQ19}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q6IQ19}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q6IQ19}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22493317}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q6IQ19}. Cell projection, axon {ECO:0000250|UniProtKB:Q6IQ19}. Cell projection, cilium {ECO:0000250|UniProtKB:Q6IQ19}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q6IQ19}. Note=Localizes at specific foci at the apical surface of neuroepithelial cells where cilia form along the brain ventricle lumen. {ECO:0000269|PubMed:22493317}. DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. Expressed ubiquitously in the developing embryo. Strongly expressed in the somites and brain at 16 to 26 hours post-fertilization (hpf). {ECO:0000269|PubMed:22493317}. SIMILARITY: Belongs to the CCSAP family. {ECO:0000305}. SEQUENCE CAUTION: Sequence=AAH63997.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH97150.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
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