UniProt ID: A0A8M1QV85 |
CAUTION: Lacks conserved residue(s) required for the propagation of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. |
UniProt ID: E9QJQ6 |
FUNCTION: Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells (By similarity). Essential factor in the regulation of muscle development including myogenesis (PubMed:22371254, Ref.4). Likely plays a key role in muscle cell proliferation, adhesion and motility (PubMed:22371254, Ref.4). May control the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (Ref.4). {ECO:0000250|UniProtKB:Q96KG7, ECO:0000269|PubMed:22371254, ECO:0000269|Ref.4}. SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96KG7}; Single-pass type I membrane protein {ECO:0000305}. DISRUPTION PHENOTYPE: Morpholino knockdown causes widespread disruption of myofibril organization and decreased muscle striation resulting in curled or bent tails, impaired swimming, and reduced motility in response to touch. Severely bent tails result from subtle abnormalities in somite boundaries and abundant gaps between myofibers. {ECO:0000269|PubMed:22371254}. SIMILARITY: Belongs to the MEGF family. {ECO:0000305}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |