UniProt ID: E7EZG2
FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons (By similarity). Required for the regulation of neurite branching and motor neuron axon guidance (PubMed:27259756). {ECO:0000250|UniProtKB:Q9Z1N3, ECO:0000269|PubMed:27259756}.
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q9Z1N3}. Cell junction, synapse {ECO:0000250|UniProtKB:Q8C170}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q8C170}. Note=Localized in the cytoplasm of cell bodies, dendrites and axons with occasional hints of an enrichment near the plasma membrane. Localized at the neuromuscular junction. {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}.
DISRUPTION PHENOTYPE: Morpholino-induced knockdown affects tail morphology, and causes cardiac edema and abnormal swimming in response to tactile stimulation. Morphants show aberrant axons, either short or over-extended, with some axons appearing to branch to the adjacent myotome. {ECO:0000269|PubMed:27259756}.
SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. {ECO:0000255|PROSITE-ProRule:PRU00782}.
This information was provided by UniProt through a collaboration with ZFIN. (1)