UniProt ID: A2THE9 |
FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. {ECO:0000256|RuleBase:RU365061}. CATALYTIC ACTIVITY: Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.49; Evidence={ECO:0000256|ARBA:ARBA00024557, ECO:0000256|RuleBase:RU365061}; SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365061}. Chromosome, telomere {ECO:0000256|RuleBase:RU365061}. SIMILARITY: Belongs to the reverse transcriptase family. Telomerase subfamily. {ECO:0000256|ARBA:ARBA00008001, ECO:0000256|RuleBase:RU365061}. |
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