UniProt ID: A7UA95 |
FUNCTION: Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. {ECO:0000269|PubMed:17704304}. SUBUNIT: Interacts with RAP1A; in a GTP-dependent manner. {ECO:0000250}. TISSUE SPECIFICITY: Ubiquitously expressed and enriched in the anterior part of the embryos. {ECO:0000269|PubMed:17704304}. DEVELOPMENTAL STAGE: Present at very low level in one-cell embryos, suggesting the presence of maternally deposited transcripts. Increases upon the onset of zygotic transcription (around the 1000-cell stage), eventually peaking at 72 hpf. {ECO:0000269|PubMed:17704304}. MISCELLANEOUS: Knockdown results in multiple defects in neural crest- derived lineages such as cartilage, pigment cells, and enteric neurons. SIMILARITY: Belongs to the RADIL family. {ECO:0000305}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |