UniProt ID: P86839 |
FUNCTION: Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). Required for brain and eye development. {ECO:0000250, ECO:0000269|PubMed:20174467}. SUBUNIT: Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha- internexin, preferentially forms heterodimers (By similarity). {ECO:0000250}. TISSUE SPECIFICITY: Widely expressed throughout the developing nervous system at 24 hours post-fertilization (hpf). As development progresses, expression becomes restricted to proliferative zones of the developing and postembryonic central nervous system. In the peripheral nervous system, expressed in the cranial ganglia. Also expressed in mesodermal muscle precursor cells and in cranial mesenchymal tissue. {ECO:0000269|PubMed:17651502}. DEVELOPMENTAL STAGE: Expression is not detected before the 3-somite stage at 10-11 hours post-fertilization. Earliest expression is detected during mid-neurulation. {ECO:0000269|PubMed:17651502}. SIMILARITY: Belongs to the intermediate filament family. {ECO:0000255|PROSITE-ProRule:PRU01188}. |
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