UniProt ID: B0S5G3 |
FUNCTION: Postsynaptic adhesion molecule (PubMed:25463516). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with presynaptic neurexins (By similarity). {ECO:0000250|UniProtKB:Q99JH7, ECO:0000269|PubMed:25463516}. SUBUNIT: Homooligomer and heterooligomer; mediates both homophilic and heterophilc interactions with clstn1 and clstn3 paralogs via cadherin domains. {ECO:0000269|PubMed:25463516}. SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9ER65}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ER65}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9ER65}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9ER65}. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization. {ECO:0000250|UniProtKB:Q9ER65}. TISSUE SPECIFICITY: By 48 hours post-fertilization (hpf), widely expressed in the brain, with strong expression in the telencephalon and the midbrain. {ECO:0000269|PubMed:25463516}. DEVELOPMENTAL STAGE: Expression is detected at 4.5 hours post- fertilization (hpf) (PubMed:25463516). During development, weakly expressed in the brain, with some expression detectable in the telencephalon and diencephalon (PubMed:25463516). In the spinal cord, expression is restricted to an array of large dorsal neurons and small clusters of ventral neurons, likely Rohon-Beard cells and primary motoneurons, respectively (PubMed:25463516). {ECO:0000269|PubMed:25463516}. DOMAIN: Binds synaptic Ca(2+) with its cytoplasmic domain. {ECO:0000250|UniProtKB:Q9EPL2}. SIMILARITY: Belongs to the calsyntenin family. {ECO:0000305}. |
UniProt ID: A0A8M3B0F0 |
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004614}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004614}. Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00035006}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00035006}. SIMILARITY: Belongs to the calsyntenin family. {ECO:0000256|ARBA:ARBA00035015}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |