UniProt ID: A0A8M1Q7N6 |
FUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol. {ECO:0000256|PIRNR:PIRNR018269}. CATALYTIC ACTIVITY: Reaction=1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3- cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45656, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77126, ChEBI:CHEBI:85351; Evidence={ECO:0000256|ARBA:ARBA00001021}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45657; Evidence={ECO:0000256|ARBA:ARBA00001021}; CATALYTIC ACTIVITY: Reaction=1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'- diphosphate + diphosphate; Xref=Rhea:RHEA:45672, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77128, ChEBI:CHEBI:85355; Evidence={ECO:0000256|ARBA:ARBA00001056}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45673; Evidence={ECO:0000256|ARBA:ARBA00001056}; CATALYTIC ACTIVITY: Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45676, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:74546, ChEBI:CHEBI:85356; Evidence={ECO:0000256|ARBA:ARBA00000060}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45677; Evidence={ECO:0000256|ARBA:ARBA00000060}; CATALYTIC ACTIVITY: Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphate + CTP + H(+) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45652, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:72864, ChEBI:CHEBI:85350; Evidence={ECO:0000256|ARBA:ARBA00001617}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45653; Evidence={ECO:0000256|ARBA:ARBA00001617}; CATALYTIC ACTIVITY: Reaction=1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2- (4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'- diphosphate + diphosphate; Xref=Rhea:RHEA:45668, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77130, ChEBI:CHEBI:85354; Evidence={ECO:0000256|ARBA:ARBA00000281}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45669; Evidence={ECO:0000256|ARBA:ARBA00000281}; CATALYTIC ACTIVITY: Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45648, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77091, ChEBI:CHEBI:85349; Evidence={ECO:0000256|ARBA:ARBA00001729}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45649; Evidence={ECO:0000256|ARBA:ARBA00001729}; CATALYTIC ACTIVITY: Reaction=1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)- sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45660, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77098, ChEBI:CHEBI:85352; Evidence={ECO:0000256|ARBA:ARBA00000515}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45661; Evidence={ECO:0000256|ARBA:ARBA00000515}; CATALYTIC ACTIVITY: Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45664, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:74560, ChEBI:CHEBI:85353; Evidence={ECO:0000256|ARBA:ARBA00000859}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45665; Evidence={ECO:0000256|ARBA:ARBA00000859}; CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2- diacyl-sn-glycerol + diphosphate; Xref=Rhea:RHEA:16229, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608; EC=2.7.7.41; Evidence={ECO:0000256|ARBA:ARBA00001902}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16230; Evidence={ECO:0000256|ARBA:ARBA00001902}; PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}. PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP- diacylglycerol from sn-glycerol 3-phosphate: step 3/3. {ECO:0000256|ARBA:ARBA00005119, ECO:0000256|PIRNR:PIRNR018269, ECO:0000256|RuleBase:RU003938}. SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. SIMILARITY: Belongs to the CDS family. {ECO:0000256|ARBA:ARBA00010185, ECO:0000256|PIRNR:PIRNR018269, ECO:0000256|RuleBase:RU003938}. |
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