UniProt ID: A0A8M9PL33 |
CATALYTIC ACTIVITY: Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119}; DOMAIN: The DHHC domain is required for palmitoyltransferase activity. {ECO:0000256|RuleBase:RU079119}. SIMILARITY: Belongs to the DHHC palmitoyltransferase family. {ECO:0000256|RuleBase:RU079119}. |
UniProt ID: A0A8M9PQZ2 |
CATALYTIC ACTIVITY: Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119}; DOMAIN: The DHHC domain is required for palmitoyltransferase activity. {ECO:0000256|RuleBase:RU079119}. SIMILARITY: Belongs to the DHHC palmitoyltransferase family. {ECO:0000256|RuleBase:RU079119}. |
UniProt ID: E7F021 |
FUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (By similarity). Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering (By similarity). Acts as an inhibitor of the NLRP3 inflammasome by mediating palmitoylation of NLRP3, thereby promoting NLRP3 degradation by the chaperone-mediated autophagy (CMA) process (By similarity). {ECO:0000250|UniProtKB:Q8VC90, ECO:0000250|UniProtKB:Q96GR4}. CATALYTIC ACTIVITY: Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence={ECO:0000250|UniProtKB:Q8VC90}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence={ECO:0000250|UniProtKB:Q8VC90}; SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8VC90}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96GR4}; Multi-pass membrane protein {ECO:0000255}. DOMAIN: The DHHC domain is required for palmitoyltransferase activity. {ECO:0000250|UniProtKB:Q8IUH5}. SIMILARITY: Belongs to the DHHC palmitoyltransferase family. {ECO:0000305}. |
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