UniProt ID: E7FCQ8 |
FUNCTION: Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|RuleBase:RU364134}. SUBUNIT: Component of the Mediator complex. {ECO:0000256|RuleBase:RU364134}. SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364134}. SIMILARITY: Belongs to the Mediator complex subunit 13 family. {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}. |
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