UniProt ID: A5PKS5 |
FUNCTION: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. {ECO:0000256|ARBA:ARBA00025266}. CATALYTIC ACTIVITY: Reaction=7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8- tetrahydropterin + H(+) + triphosphate; Xref=Rhea:RHEA:22048, ChEBI:CHEBI:15378, ChEBI:CHEBI:18036, ChEBI:CHEBI:58462, ChEBI:CHEBI:136564; EC=4.2.3.12; Evidence={ECO:0000256|PIRNR:PIRNR006113}; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|PIRNR:PIRNR006113, ECO:0000256|PIRSR:PIRSR006113-2}; Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRNR:PIRNR006113, ECO:0000256|PIRSR:PIRSR006113-2}; PATHWAY: Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3. {ECO:0000256|ARBA:ARBA00005126, ECO:0000256|PIRNR:PIRNR006113}. SIMILARITY: Belongs to the PTPS family. {ECO:0000256|ARBA:ARBA00009164, ECO:0000256|PIRNR:PIRNR006113}. |
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