UniProt ID: A0A8M6YZA4 |
FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000256|ARBA:ARBA00002001}. SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. SIMILARITY: Belongs to the histone H3 family. {ECO:0000256|ARBA:ARBA00010343}. SIMILARITY: Belongs to the histone H4 family. {ECO:0000256|ARBA:ARBA00006564}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |