UniProt ID: A4QP81 |
FUNCTION: Putative ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. {ECO:0000250|UniProtKB:Q8K385}. COFACTOR: Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence={ECO:0000250|UniProtKB:Q53TN4}; Note=Binds 2 heme b groups non-covalently. {ECO:0000250|UniProtKB:Q53TN4}; SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. SIMILARITY: Belongs to the FRRS1 family. {ECO:0000305}. CAUTION: The cytochrome b561 domain lacks the conserved His residue that binds iron in the heme. The reductase activity is therefore unsure in vivo. {ECO:0000305}. |
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