UniProt ID: A7YE96 |
FUNCTION: Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity). Required for polyglutamylation of axonemal tubulin, which is a prerequisite for correct assembly of cilia and for normal cilia beat amplitude. Does not seem to be required for neuronal microtubule polyglutamylation. {ECO:0000250, ECO:0000269|PubMed:17761526}. SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:17761526}. TISSUE SPECIFICITY: Localizes to the cilia of many ciliated epithelial cell types including pronephric cells, olfactory placode, the brain ventricle and lateral line organs. {ECO:0000269|PubMed:17761526}. DEVELOPMENTAL STAGE: Maternally expressed. First detected in Kupffer's vesicle of seven somite embryos and the lateral mesoderm of 11 somite embryos. By 24 to 30 hours post-fertilization (hpf), expression becomes widespread within the central nervous system and the pronephros and parallels the development of multiciliated cells. During later stages of larval development (54 hpf), expression continues throughout the pronephros and intensifies in the olfactory placode and lateral line organs. {ECO:0000269|PubMed:17761526}. SIMILARITY: Belongs to the TTC30/dfy-1/fleer family. {ECO:0000305}. SEQUENCE CAUTION: Sequence=ABV08791.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
UniProt ID: A0A8M9PR90 |
FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. {ECO:0000256|RuleBase:RU367070}. SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138, ECO:0000256|RuleBase:RU367070}. SIMILARITY: Belongs to the TTC30/dfy-1/fleer family. {ECO:0000256|ARBA:ARBA00009522, ECO:0000256|RuleBase:RU367070}. |
UniProt ID: A0A8M9P934 |
FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. {ECO:0000256|RuleBase:RU367070}. SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138, ECO:0000256|RuleBase:RU367070}. SIMILARITY: Belongs to the TTC30/dfy-1/fleer family. {ECO:0000256|ARBA:ARBA00009522, ECO:0000256|RuleBase:RU367070}. |
UniProt ID: A0A8M9PYI9 |
FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. {ECO:0000256|RuleBase:RU367070}. SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138, ECO:0000256|RuleBase:RU367070}. SIMILARITY: Belongs to the TTC30/dfy-1/fleer family. {ECO:0000256|ARBA:ARBA00009522, ECO:0000256|RuleBase:RU367070}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |