UniProt ID: A1L258 |
FUNCTION: Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate (By similarity). Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC) (By similarity). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC (By similarity). {ECO:0000250|UniProtKB:Q8N465}. CATALYTIC ACTIVITY: Reaction=(R)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2; Xref=Rhea:RHEA:38295, ChEBI:CHEBI:13193, ChEBI:CHEBI:15801, ChEBI:CHEBI:16810, ChEBI:CHEBI:17499; EC=1.1.99.39; Evidence={ECO:0000250|UniProtKB:Q8N465}; CATALYTIC ACTIVITY: Reaction=(R)-malate + A = AH2 + oxaloacetate; Xref=Rhea:RHEA:67460, ChEBI:CHEBI:13193, ChEBI:CHEBI:15588, ChEBI:CHEBI:16452, ChEBI:CHEBI:17499; Evidence={ECO:0000250|UniProtKB:Q8N465}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67461; Evidence={ECO:0000250|UniProtKB:Q8N465}; COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000305}; SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}. SIMILARITY: Belongs to the FAD-binding oxidoreductase/transferase type 4 family. {ECO:0000305}. |
UniProt ID: F1R1R3 |
COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|ARBA:ARBA00001974}; SIMILARITY: Belongs to the FAD-binding oxidoreductase/transferase type 4 family. {ECO:0000256|ARBA:ARBA00008000}. |
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