UniProt ID: Q3ZMH1 |
FUNCTION: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)- dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D- lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5- aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1 (PubMed:17255103). Catalyzes passive carrier mediated diffusion of iodide (By similarity). Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane (By similarity). Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline) (By similarity). Can mediate the transport of chloride, bromide, iodide and nitrate ions when external concentration of sodium ions is reduced (By similarity). {ECO:0000250|UniProtKB:Q8N695, ECO:0000269|PubMed:17255103}. CATALYTIC ACTIVITY: Reaction=(S)-lactate(out) + 2 Na(+)(out) = (S)-lactate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:72935, ChEBI:CHEBI:16651, ChEBI:CHEBI:29101; Evidence={ECO:0000269|PubMed:17255103}; CATALYTIC ACTIVITY: Reaction=2 Na(+)(out) + propanoate(out) = 2 Na(+)(in) + propanoate(in); Xref=Rhea:RHEA:72939, ChEBI:CHEBI:17272, ChEBI:CHEBI:29101; Evidence={ECO:0000250|UniProtKB:Q8N695}; CATALYTIC ACTIVITY: Reaction=2 Na(+)(out) + pyruvate(out) = 2 Na(+)(in) + pyruvate(in); Xref=Rhea:RHEA:72943, ChEBI:CHEBI:15361, ChEBI:CHEBI:29101; Evidence={ECO:0000269|PubMed:17255103}; CATALYTIC ACTIVITY: Reaction=acetate(out) + 2 Na(+)(out) = acetate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:72947, ChEBI:CHEBI:29101, ChEBI:CHEBI:30089; Evidence={ECO:0000250|UniProtKB:Q8N695}; CATALYTIC ACTIVITY: Reaction=butanoate(out) + 2 Na(+)(out) = butanoate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:72951, ChEBI:CHEBI:17968, ChEBI:CHEBI:29101; Evidence={ECO:0000269|PubMed:17255103}; CATALYTIC ACTIVITY: Reaction=2 Na(+)(out) + nicotinate(out) = 2 Na(+)(in) + nicotinate(in); Xref=Rhea:RHEA:72955, ChEBI:CHEBI:29101, ChEBI:CHEBI:32544; Evidence={ECO:0000269|PubMed:17255103}; CATALYTIC ACTIVITY: Reaction=(R)-3-hydroxybutanoate(out) + 2 Na(+)(out) = (R)-3- hydroxybutanoate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:72959, ChEBI:CHEBI:10983, ChEBI:CHEBI:29101; Evidence={ECO:0000269|PubMed:17255103}; CATALYTIC ACTIVITY: Reaction=acetoacetate(out) + 2 Na(+)(out) = acetoacetate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:72963, ChEBI:CHEBI:13705, ChEBI:CHEBI:29101; Evidence={ECO:0000269|PubMed:17255103}; CATALYTIC ACTIVITY: Reaction=4-methyl-2-oxopentanoate(out) + 2 Na(+)(out) = 4-methyl-2- oxopentanoate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:72967, ChEBI:CHEBI:17865, ChEBI:CHEBI:29101; Evidence={ECO:0000250|UniProtKB:Q8BYF6}; CATALYTIC ACTIVITY: Reaction=5-oxo-L-proline(out) + 2 Na(+)(out) = 5-oxo-L-proline(in) + 2 Na(+)(in); Xref=Rhea:RHEA:72971, ChEBI:CHEBI:29101, ChEBI:CHEBI:58402; Evidence={ECO:0000250|UniProtKB:Q8N695}; CATALYTIC ACTIVITY: Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324, ChEBI:CHEBI:16382; Evidence={ECO:0000250|UniProtKB:Q8N695}; CATALYTIC ACTIVITY: Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence={ECO:0000250|UniProtKB:Q8N695}; CATALYTIC ACTIVITY: Reaction=nitrate(in) = nitrate(out); Xref=Rhea:RHEA:34923, ChEBI:CHEBI:17632; Evidence={ECO:0000250|UniProtKB:Q8N695}; CATALYTIC ACTIVITY: Reaction=bromide(in) = bromide(out); Xref=Rhea:RHEA:75383, ChEBI:CHEBI:15858; Evidence={ECO:0000250|UniProtKB:Q8N695}; BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=169 uM for L-lactate {ECO:0000269|PubMed:17255103}; KM=535 uM for nicotinate {ECO:0000269|PubMed:17255103}; SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q8N695}; Multi-pass membrane protein {ECO:0000255}. TISSUE SPECIFICITY: Expressed in brain and eye 24 hours post- fertilization. In the 5 day old embryo, detected in swim bladder, pronephros (embryonic kidney), pronephric tube, and pronephric ducts, brain, trabecular bar, eyes, otic capsule, stomach, gall bladder, and gut. {ECO:0000269|PubMed:17255103}. SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO:0000255}. |
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