UniProt ID: A5WVX1 |
FUNCTION: Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (eef1a1 and eef1a2) at two different positions, and is therefore involved in the regulation of mRNA translation. Via its C-terminus, methylates the N-terminus of eef1a1 and eef1a2. Via its N-terminus dimethylates lysine residues of eef1a1 and eef1a2. {ECO:0000250|UniProtKB:Q8N6R0}. CATALYTIC ACTIVITY: Reaction=L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)- methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:51736, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13053, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; Evidence={ECO:0000250|UniProtKB:Q8N6R0}; CATALYTIC ACTIVITY: Reaction=N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54196, Rhea:RHEA-COMP:13053, Rhea:RHEA-COMP:13827, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; Evidence={ECO:0000250|UniProtKB:Q8N6R0}; CATALYTIC ACTIVITY: Reaction=N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl- L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L- glutamyl-[protein] + 3 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:58440, Rhea:RHEA-COMP:15140, Rhea:RHEA-COMP:15143, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:142597, ChEBI:CHEBI:142600; Evidence={ECO:0000250|UniProtKB:Q8N6R0}; SIMILARITY: Belongs to the methyltransferase superfamily. {ECO:0000305}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |