UniProt ID: Q08CN9 |
FUNCTION: May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000250}. CATALYTIC ACTIVITY: Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; PATHWAY: Protein modification; protein ubiquitination. SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q8NHG8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8NHG8}. Lysosome membrane {ECO:0000250|UniProtKB:Q8NHG8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8NHG8}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q8NHG8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8NHG8}. |
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