UniProt ID: Q08CC2 |
FUNCTION: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. {ECO:0000256|PIRNR:PIRNR000858}. CATALYTIC ACTIVITY: Reaction=a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate; Xref=Rhea:RHEA:24564, ChEBI:CHEBI:30031, ChEBI:CHEBI:35973, ChEBI:CHEBI:57292, ChEBI:CHEBI:90726; EC=2.8.3.5; Evidence={ECO:0000256|PIRNR:PIRNR000858}; PATHWAY: Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00004753, ECO:0000256|PIRNR:PIRNR000858}. SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. SIMILARITY: Belongs to the 3-oxoacid CoA-transferase family. {ECO:0000256|ARBA:ARBA00007154, ECO:0000256|PIRNR:PIRNR000858}. |
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