UniProt ID: A0A8M3B785 |
FUNCTION: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L- methionine-dependent methyltransferase. {ECO:0000256|HAMAP- Rule:MF_03044}. SUBUNIT: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S- adenosyl-L-methionine. {ECO:0000256|HAMAP-Rule:MF_03044}. SIMILARITY: Belongs to the BMT2 family. {ECO:0000256|HAMAP- Rule:MF_03044}. |
UniProt ID: Q0P410 |
FUNCTION: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L- methionine-dependent methyltransferase. {ECO:0000255|HAMAP- Rule:MF_03044}. SUBUNIT: Interacts with the GATOR1 complex; interaction is disrupted when bmt2/samtor binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when bmt2/samtor binds S- adenosyl-L-methionine. {ECO:0000255|HAMAP-Rule:MF_03044}. SIMILARITY: Belongs to the BMT2 family. {ECO:0000255|HAMAP- Rule:MF_03044}. |
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