UniProt ID: Q1ECW2 |
FUNCTION: Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late- response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience. {ECO:0000250|UniProtKB:Q8BGD7}. SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. {ECO:0000250|UniProtKB:Q8BGD7}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BGD7, ECO:0000255|PROSITE-ProRule:PRU00981}. TISSUE SPECIFICITY: Brain-specific. {ECO:0000269|PubMed:25538572}. INDUCTION: Expression is regulated by neuronal activity. {ECO:0000269|PubMed:25538572}. |
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