UniProt ID: A0A8M9QEE8 |
CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000256|RuleBase:RU366025}; SIMILARITY: Belongs to the peptidase C19 family. {ECO:0000256|RuleBase:RU366025}. |
UniProt ID: A0A8M9QMM5 |
CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000256|RuleBase:RU366025}; SIMILARITY: Belongs to the peptidase C19 family. {ECO:0000256|RuleBase:RU366025}. |
UniProt ID: A6H8I0 |
FUNCTION: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators, where it is required for transcription (By similarity). {ECO:0000250}. CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; SUBUNIT: Component of some SAGA transcription coactivator-HAT complexes. {ECO:0000250}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5DU02}. SIMILARITY: Belongs to the peptidase C19 family. UBP8 subfamily. {ECO:0000305}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |