UniProt ID: Q1LWC3 |
FUNCTION: Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). {ECO:0000256|RuleBase:RU365008}. CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-5-phosphate) + phosphate; Xref=Rhea:RHEA:25674, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57795, ChEBI:CHEBI:58456; EC=3.1.3.78; Evidence={ECO:0000256|ARBA:ARBA00001261, ECO:0000256|RuleBase:RU365008}; SUBCELLULAR LOCATION: Endosome membrane {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004337}. Late endosome membrane {ECO:0000256|ARBA:ARBA00004107, ECO:0000256|RuleBase:RU365008}; Multi- pass membrane protein {ECO:0000256|ARBA:ARBA00004107, ECO:0000256|RuleBase:RU365008}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004155, ECO:0000256|RuleBase:RU365008}; Multi- pass membrane protein {ECO:0000256|ARBA:ARBA00004155, ECO:0000256|RuleBase:RU365008}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. |
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