UniProt ID: Q2PS19 |
FUNCTION: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). {ECO:0000256|RuleBase:RU367046}. CATALYTIC ACTIVITY: Reaction=H2O + L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl- [protein] + H2O2 + NH4(+); Xref=Rhea:RHEA:24544, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:12448, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:28938, ChEBI:CHEBI:29969, ChEBI:CHEBI:131803; EC=1.4.3.13; Evidence={ECO:0000256|RuleBase:RU367046}; COFACTOR: Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence={ECO:0000256|ARBA:ARBA00001935, ECO:0000256|RuleBase:RU367046}; SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000256|RuleBase:RU367046}. PTM: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. {ECO:0000256|RuleBase:RU367046}. SIMILARITY: Belongs to the lysyl oxidase family. {ECO:0000256|ARBA:ARBA00007492, ECO:0000256|RuleBase:RU367046}. |
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