UniProt ID: A0A0R4IT36 |
FUNCTION: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. {ECO:0000256|PIRNR:PIRNR037387}. SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR037387}; Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR037387}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004163, ECO:0000256|PIRNR:PIRNR037387}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004163}. Membrane {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}. SIMILARITY: Belongs to the junctophilin family. {ECO:0000256|ARBA:ARBA00008599, ECO:0000256|PIRNR:PIRNR037387}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |