UniProt ID: Q1L8X2 |
FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with ppp2r2d (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). {ECO:0000250}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. PTM: Phosphorylation at Ser-74 by gwl during mitosis is essential for interaction with ppp2r2d (PR55-delta) and subsequent inactivation of PP2A. {ECO:0000250}. SIMILARITY: Belongs to the endosulfine family. {ECO:0000305}. |
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