UniProt ID: B3DGI6 |
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. SIMILARITY: Belongs to the ripply family. {ECO:0000256|ARBA:ARBA00006944}. |
UniProt ID: Q2WG80 |
FUNCTION: Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites. {ECO:0000269|PubMed:16326386}. SUBUNIT: Interacts with gro2 via the WRPW motif. {ECO:0000269|PubMed:16326386}. SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16326386}. TISSUE SPECIFICITY: Expressed in the embryonic anterior presomitic mesoderm and in newly formed somites. {ECO:0000269|PubMed:16326386}. DOMAIN: The ripply homology domain is required for transcriptional repression. {ECO:0000250}. DOMAIN: The WRPW motif is required for binding to tle/groucho proteins. {ECO:0000269|PubMed:16326386}. MISCELLANEOUS: Named after the expression pattern, which decreases in a posterior to anterior direction in somites like a ripple. {ECO:0000269|PubMed:16326386}. SIMILARITY: Belongs to the ripply family. {ECO:0000305}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |