UniProt ID: Q71N41 |
FUNCTION: Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development. {ECO:0000250|UniProtKB:Q14353}. CATALYTIC ACTIVITY: Reaction=guanidinoacetate + S-adenosyl-L-methionine = creatine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:10656, ChEBI:CHEBI:15378, ChEBI:CHEBI:57742, ChEBI:CHEBI:57856, ChEBI:CHEBI:57947, ChEBI:CHEBI:59789; EC=2.1.1.2; Evidence={ECO:0000255|PROSITE- ProRule:PRU00892}; PATHWAY: Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 2/2. SUBUNIT: Monomer. {ECO:0000250}. SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. {ECO:0000255|PROSITE- ProRule:PRU00892}. |
UniProt ID: A8E5I0 |
FUNCTION: Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. {ECO:0000256|PIRNR:PIRNR009285}. CATALYTIC ACTIVITY: Reaction=guanidinoacetate + S-adenosyl-L-methionine = creatine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:10656, ChEBI:CHEBI:15378, ChEBI:CHEBI:57742, ChEBI:CHEBI:57856, ChEBI:CHEBI:57947, ChEBI:CHEBI:59789; EC=2.1.1.2; Evidence={ECO:0000256|PIRNR:PIRNR009285}; PATHWAY: Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 2/2. {ECO:0000256|ARBA:ARBA00004820, ECO:0000256|PIRNR:PIRNR009285}. SUBUNIT: Monomer. {ECO:0000256|PIRNR:PIRNR009285}. SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. {ECO:0000256|PIRNR:PIRNR009285}. |
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