UniProt ID: Q503L9 |
FUNCTION: Functions as a redox-dependent negative regulator of the Wnt signaling pathway. {ECO:0000250}. CATALYTIC ACTIVITY: Reaction=[protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + NADH; Xref=Rhea:RHEA:18749, Rhea:RHEA-COMP:10593, Rhea:RHEA- COMP:10594, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.8.1.8; CATALYTIC ACTIVITY: Reaction=[protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) + NADPH; Xref=Rhea:RHEA:18753, Rhea:RHEA-COMP:10593, Rhea:RHEA- COMP:10594, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.8; SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P97346}. Nucleus {ECO:0000250|UniProtKB:P97346}. SIMILARITY: Belongs to the nucleoredoxin family. {ECO:0000305}. |
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