UniProt ID: A0A8M9PHA7 |
FUNCTION: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. {ECO:0000256|HAMAP-Rule:MF_03023}. CATALYTIC ACTIVITY: Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; Evidence={ECO:0000256|HAMAP-Rule:MF_03023}; ACTIVITY REGULATION: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1. {ECO:0000256|HAMAP- Rule:MF_03023}. SUBUNIT: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. {ECO:0000256|HAMAP-Rule:MF_03023}. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186, ECO:0000256|HAMAP-Rule:MF_03023}. Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03023}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|HAMAP- Rule:MF_03023}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000256|HAMAP-Rule:MF_03023}. Note=Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1. {ECO:0000256|HAMAP-Rule:MF_03023}. SIMILARITY: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. {ECO:0000256|HAMAP-Rule:MF_03023}. |
UniProt ID: Q5RII9 |
FUNCTION: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. {ECO:0000255|HAMAP-Rule:MF_03023}. CATALYTIC ACTIVITY: Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; Evidence={ECO:0000255|HAMAP-Rule:MF_03023}; ACTIVITY REGULATION: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with katnb1. {ECO:0000255|HAMAP- Rule:MF_03023}. SUBUNIT: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with katnb1, which may serve as a targeting subunit. {ECO:0000255|HAMAP-Rule:MF_03023}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03023}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03023}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000255|HAMAP-Rule:MF_03023}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:O75449}. Note=Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with katnb1. {ECO:0000255|HAMAP- Rule:MF_03023}. SIMILARITY: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. {ECO:0000255|HAMAP-Rule:MF_03023}. |
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