UniProt ID: A0A8M9PXK1 |
CATALYTIC ACTIVITY: Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4; Evidence={ECO:0000256|ARBA:ARBA00001663}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946}; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. SIMILARITY: Belongs to the CCR4/nocturin family. {ECO:0000256|ARBA:ARBA00010774}. |
UniProt ID: A2BHJ4 |
FUNCTION: Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression (By similarity). {ECO:0000250}. CATALYTIC ACTIVITY: Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4; Evidence={ECO:0000250|UniProtKB:Q96LI5}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:Q96LI5}; Note=Binds 2 magnesium ions, but the ions interact each with only 1 or 2 residues. {ECO:0000250|UniProtKB:Q96LI5}; SUBUNIT: Component of the CCR4-NOT complex. {ECO:0000250|UniProtKB:Q96LI5}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96LI5}. Nucleus {ECO:0000250|UniProtKB:Q96LI5}. Note=Predominantly cytoplasmic. {ECO:0000250|UniProtKB:Q96LI5}. SIMILARITY: Belongs to the CCR4/nocturin family. {ECO:0000305}. |
UniProt ID: B2GPA8 |
CATALYTIC ACTIVITY: Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4; Evidence={ECO:0000256|ARBA:ARBA00001663}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946}; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. SIMILARITY: Belongs to the CCR4/nocturin family. {ECO:0000256|ARBA:ARBA00010774}. |
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