UniProt ID: Q502J0 |
FUNCTION: Exhibits both acyltransferase and acetyltransferase activities (By similarity). Activity is calcium-dependent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1- acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2- diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O- alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl- sn-glycero-3-phosphocholine (PAF) (By similarity). {ECO:0000250|UniProtKB:Q7L5N7, ECO:0000250|UniProtKB:Q8BYI6}. CATALYTIC ACTIVITY: Reaction=a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2- diacyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:12937, ChEBI:CHEBI:57287, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168, ChEBI:CHEBI:58342; EC=2.3.1.23; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; CATALYTIC ACTIVITY: Reaction=1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O- alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:18461, ChEBI:CHEBI:30909, ChEBI:CHEBI:36707, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.67; Evidence={ECO:0000250|UniProtKB:Q8BYI6}; CATALYTIC ACTIVITY: Reaction=a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl- sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:19709, ChEBI:CHEBI:57287, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342, ChEBI:CHEBI:58608; EC=2.3.1.51; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; CATALYTIC ACTIVITY: Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:10344, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:77286, ChEBI:CHEBI:77287; EC=2.3.1.25; Evidence={ECO:0000250|UniProtKB:Q8BYI6}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:33187, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57518, ChEBI:CHEBI:64839; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33188; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37131, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74544, ChEBI:CHEBI:74546; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37132; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; CATALYTIC ACTIVITY: Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37143, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74544, ChEBI:CHEBI:74551; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37144; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate = 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37151, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74554, ChEBI:CHEBI:74556; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37152; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37163, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74560, ChEBI:CHEBI:74565; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37164; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; CATALYTIC ACTIVITY: Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37155, ChEBI:CHEBI:57287, ChEBI:CHEBI:74307, ChEBI:CHEBI:74544, ChEBI:CHEBI:74558; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37156; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; CATALYTIC ACTIVITY: Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero- 3-phosphate = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn- glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37159, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:74544, ChEBI:CHEBI:74563; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37160; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; CATALYTIC ACTIVITY: Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37171, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:74544, ChEBI:CHEBI:74579; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37172; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; CATALYTIC ACTIVITY: Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37175, ChEBI:CHEBI:57287, ChEBI:CHEBI:74309, ChEBI:CHEBI:74544, ChEBI:CHEBI:74578; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37176; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; CATALYTIC ACTIVITY: Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37595, ChEBI:CHEBI:57287, ChEBI:CHEBI:74544, ChEBI:CHEBI:75104, ChEBI:CHEBI:75105; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37596; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3- phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphocholine + CoA; Xref=Rhea:RHEA:35991, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35992; Evidence={ECO:0000250|UniProtKB:Q7L5N7}; CATALYTIC ACTIVITY: Reaction=1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O- hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37719, ChEBI:CHEBI:44811, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64496; Evidence={ECO:0000250|UniProtKB:Q8BYI6}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37720; Evidence={ECO:0000250|UniProtKB:Q8BYI6}; CATALYTIC ACTIVITY: Reaction=1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O- octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37699, ChEBI:CHEBI:52450, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:75216; Evidence={ECO:0000250|UniProtKB:Q8BYI6}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37700; Evidence={ECO:0000250|UniProtKB:Q8BYI6}; CATALYTIC ACTIVITY: Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1- hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37703, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:72998, ChEBI:CHEBI:75219; Evidence={ECO:0000250|UniProtKB:Q8BYI6}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37704; Evidence={ECO:0000250|UniProtKB:Q8BYI6}; CATALYTIC ACTIVITY: Reaction=1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1- octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37707, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:73858, ChEBI:CHEBI:75220; Evidence={ECO:0000250|UniProtKB:Q8BYI6}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37708; Evidence={ECO:0000250|UniProtKB:Q8BYI6}; CATALYTIC ACTIVITY: Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA = 1- O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37711, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:77287, ChEBI:CHEBI:78566; Evidence={ECO:0000250|UniProtKB:Q8BYI6}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37712; Evidence={ECO:0000250|UniProtKB:Q8BYI6}; CATALYTIC ACTIVITY: Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn- glycero-3-phosphocholine = 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37747, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:75216, ChEBI:CHEBI:75245; Evidence={ECO:0000250|UniProtKB:Q8BYI6}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37748; Evidence={ECO:0000250|UniProtKB:Q8BYI6}; PATHWAY: Lipid metabolism; phospholipid metabolism. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q7L5N7}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q7L5N7}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8BYI6}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q7L5N7}. Cell membrane {ECO:0000250|UniProtKB:Q8BYI6}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q7L5N7}. Lipid droplet {ECO:0000250|UniProtKB:Q7L5N7}. DOMAIN: The HXXXXD motif is essential for acyltransferase activity. {ECO:0000250|UniProtKB:Q3TFD2}. SIMILARITY: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}. |
UniProt ID: F1Q8S6 |
PATHWAY: Lipid metabolism; phospholipid metabolism. {ECO:0000256|ARBA:ARBA00005074}. PATHWAY: Phospholipid metabolism. {ECO:0000256|ARBA:ARBA00025707}. SIMILARITY: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000256|ARBA:ARBA00008655}. |
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