UniProt ID: A5WWB6 |
FUNCTION: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mad1-mad2 complexes onto kinetochores (By similarity). {ECO:0000250}. SUBUNIT: Component of the RZZ complex composed of kntc1/rod, zw10 and zwilch. {ECO:0000250}. SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore {ECO:0000250}. SIMILARITY: Belongs to the ZWILCH family. {ECO:0000305}. SEQUENCE CAUTION: Sequence=AAH95837.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI16507.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI17615.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
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