UniProt ID: A0A8M9PQQ3 |
FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. {ECO:0000256|RuleBase:RU368044}. SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU368044}. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368044}; Multi- pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368044}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. DOMAIN: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. {ECO:0000256|RuleBase:RU368044}. SIMILARITY: Belongs to the InsP3 receptor family. {ECO:0000256|ARBA:ARBA00009453, ECO:0000256|RuleBase:RU368044}. |
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