UniProt ID: A0A8M1RMF7 |
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000256|ARBA:ARBA00004611}. SIMILARITY: Belongs to the DRC9 family. {ECO:0000256|ARBA:ARBA00008222}. |
UniProt ID: A3KQH2 |
FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (camk4) activity; contributes to the regulation of camk4 signaling cascades. Plays a role in the regulation of definitive hematopoiesis via its effects on camk4 (PubMed:24787902). {ECO:0000250|UniProtKB:A8HQ54, ECO:0000269|PubMed:24787902}. SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC) (By similarity). Interacts (via IQ domain) with calmodulin when calcium levels are low. Does not interact with calmodulin in the presence of Ca(2+). Interacts with hsp70 and may form a complex with camk4 and hsp70 (PubMed:24787902). {ECO:0000250|UniProtKB:A8HQ54, ECO:0000269|PubMed:24787902}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q80W32}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q80W32}. Cell projection, cilium {ECO:0000250|UniProtKB:Q80W32}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q80W32}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8HQ54}. TISSUE SPECIFICITY: Detected in adult testis, and at lower levels in brain, kidney and ovary. {ECO:0000269|PubMed:24787902}. DOMAIN: The IQ domain mediates interaction with calmodulin when cellular Ca(2+) levels are low. {ECO:0000269|PubMed:24787902}. DISRUPTION PHENOTYPE: Morpholino knockdown of the protein leads to a severe reduction in the size of the caudal hematopoietic tissue at 72 hpf, a strong reduction in the number of myb-positive hematopoietic stem cells, and results in impaired definitive hematopoiesis. Contrary to wild-type, the expression of monocyte, macrophage and lymphoblast markers is strongly reduced. Likewise, hemoglobin levels are strongly reduced, suggesting impaired erythropoiesis. {ECO:0000269|PubMed:24787902}. SIMILARITY: Belongs to the DRC9 family. {ECO:0000305}. |
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